WASHC2C

Across TCGA pan-cancer cohorts, WASHC2C Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated WASHC2C data layer compared with 24 for mass-spec protein and 8 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher WASHC2C Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated WASHC2C expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ESCA, OV, and BRCA are the cancer types where WASHC2C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	II,III,IV	0.121	0.526	<.001	24	view →
OV	DFS	Median	II,III,IV	0.232	0.542	.022	18	view →
BRCA	OS	Median	III,IV	0.027	0.907	<.001	18	view →
CESC	OS	Median	III,IV	0.068	0.756	<.001	12	view →
BLCA	DFS	Median	All	0.130	0.599	<.001	6	view →
PRAD	DFS	Median	All	0.617	0.886	.035	6	view →
LUAD	OS	Median	III,IV	0.158	0.660	.019	6	view →
UCEC	DFS	Median	All	0.954	0.827	.019	6	view →
COAD	OS	Median	II,III,IV	0.584	0.853	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

WASHC2C–ESCA (DFS)

Open the ESCA breakdown →