WASHC2C

Across TCGA pan-cancer cohorts, WASHC2C mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated WASHC2C data layer compared with 24 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher WASHC2C mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated WASHC2C expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and UCEC are the cancer types where WASHC2C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	1.000	0.880	.012	15	view →
LUAD	DFS	Tertile	All	0.723	0.390	.003	12	view →
UCEC	DFS	Median	III,IV	0.905	0.494	.044	8	view →
PDAC	DFS	Median	All	0.363	0.216	.012	8	view →
GBM	DFS	Quartile	All	0.411	0.152	.025	6	view →
OV	DFS	Tertile	All	0.923	0.590	.040	4	view →
CCRCC	DFS	Median	All	0.822	0.641	.038	4	view →
LSCC	DFS	Median	II,III,IV	1.000	0.571	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

WASHC2C–HNSC (DFS)

Open the HNSC breakdown →