WASHC2A

Across TCGA pan-cancer cohorts, WASHC2A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated WASHC2A data layer compared with 21 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher WASHC2A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated WASHC2A expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

LSCC, HNSC, and PDAC are the cancer types where WASHC2A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	III,IV	0.492	0.913	.012	7	view →
HNSC	OS	Median	II,III,IV	0.993	0.933	.027	4	view →
PDAC	OS	Quartile	III,IV	0.236	0.571	.024	3	view →
LUAD	OS	Tertile	All	1.000	0.916	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

WASHC2A–LSCC (DFS)

Open the LSCC breakdown →