WASHC2A

Across TCGA patient cohorts, WASHC2A mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WASHC2A-associated genes across cancer lineages are S6_pS240_S244, ATM, and beta-Catenin. Each is linked with WASHC2A in more than 2 cancer types. Because this analysis shows association rather than direction, both WASHC2A-to-partner and partner-to-WASHC2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS240_S244 grouped by WASHC2A-low versus WASHC2A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WASHC2A→partner) and Y-score (partner→WASHC2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	S6_pS240_S244 →	+0.440	+3.012	.010	.018	3	3
UCEC	ATM →	-0.500	-1.857	<.001	<.001	3	3
UCEC	beta-Catenin →	+0.315	+1.807	.035	.024	3	3
COAD	S6_pS235_S236 →	+0.476	+2.820	.020	.035	3	3
UCEC	Akt_pS473 →	+0.495	+1.584	.018	.008	3	2
UCEC	Chk2_pT68 →	-0.158	-2.880	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

S6_pS240_S244 by WASHC2A expression — COAD

Explore this box plot interactively →