Across TCGA pan-cancer cohorts, WASF3-AS1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of WASF3-AS1’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where WASF3-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types WASF3-AS1 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.
THCA, HNSC, and BRCA are the cancer types where WASF3-AS1 tumor–normal differential expression is most reproducible.