WASF2

Across TCGA patient cohorts, WASF2 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WASF2-associated genes across cancer lineages are PDCD4, AMPK_alpha, and 14-3-3_beta. Each is linked with WASF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both WASF2-to-partner and partner-to-WASF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by WASF2-low versus WASF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WASF2→partner) and Y-score (partner→WASF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.447	-1.690	.009	.042	3	3
UCEC	AMPK_alpha →	-0.141	-2.222	.044	.010	3	2
UCEC	14-3-3_beta →	-0.107	-2.088	.003	.016	3	1
UCEC	eIF4E →	+0.180	+2.247	.020	.001	3	1
UCEC	FoxM1 →	+0.236	+2.247	.013	.001	3	1
UCEC	ACC_pS79 →	+0.317	+2.469	.012	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

PDCD4 by WASF2 expression — UCEC

Explore this box plot interactively →