WAS

Across TCGA pan-cancer cohorts, WAS Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated WAS data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher WAS Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated WAS expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, DLBC, and STAD are the cancer types where WAS Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.302	.003	36	view →
DLBC	OS	Median	II,III,IV	0.172	0.949	<.001	30	view →
STAD	OS	Median	All	0.108	0.545	<.001	24	view →
LIHC	DFS	Median	All	0.014	0.543	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

WAS–UCEC (DFS)

Open the UCEC breakdown →