WAS

Across TCGA patient cohorts, WAS mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WAS-associated genes across cancer lineages are FoxM1, PRAS40_pT246, and Bak. Each is linked with WAS in more than 2 cancer types. Because this analysis shows association rather than direction, both WAS-to-partner and partner-to-WAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by WAS-low versus WAS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WAS→partner) and Y-score (partner→WAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.203	+1.765	.036	.014	3	3
UCEC	PRAS40_pT246 →	+0.164	+1.428	.011	.029	3	2
UCEC	Bak →	+0.239	+2.321	.011	.005	3	2
UCEC	EGFR_pY1068 →	-0.188	-1.765	.046	.014	3	1
UCEC	Gab2 →	+0.290	+2.321	.030	.033	3	1
UCEC	JNK_pT183_Y185 →	-0.162	-2.321	.010	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

FoxM1 by WAS expression — UCEC

Explore this box plot interactively →