WAS

Across TCGA cell cohorts, WAS mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WAS-associated genes across cancer lineages are RNASE9, TBL1Y, and NEU2. Each is linked with WAS in more than 1 cancer types. Because this analysis shows association rather than direction, both WAS-to-partner and partner-to-WAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNASE9 grouped by WAS-low versus WAS-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WAS→partner) and Y-score (partner→WAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RNASE9 →	+0.012	+5.415	<.001	.004	3	2
LUNG_NSCLC_LUSC	TBL1Y →	+0.053	+4.643	<.001	.008	3	1
SKIN	NEU2 →	+0.029	+4.977	<.001	.007	3	1
SKIN	TMCO5A →	+0.062	+4.977	.003	.007	3	1
SKIN	SPRR4 →	+0.337	+4.977	<.001	.007	3	1
SKIN	TAS2R60 →	+0.050	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

RNASE9 by WAS expression — SKIN

Explore this box plot interactively →