WAS

Across TCGA cell cohorts, WAS mutation is significantly associated with the mutation status of many other genes, with 1,590 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WAS-associated genes across cancer lineages are SIGLEC12, CRY1, and LASP1. Each is linked with WAS in more than 2 cancer types. Because this analysis shows association rather than direction, both WAS-to-partner and partner-to-WAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC12 grouped by WAS-low versus WAS-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WAS→partner) and Y-score (partner→WAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SIGLEC12 →	+2.678	+2.807	.006	.006	1	3
LARGE_INTESTINE	CRY1 →	+3.584	+3.007	.008	.008	1	2
LARGE_INTESTINE	LASP1 →	+3.584	+3.007	.008	.008	1	2
LARGE_INTESTINE	MYCBP2 →	+1.485	+3.544	.003	.003	1	2
LARGE_INTESTINE	BAIAP3 →	+3.584	+4.217	<.001	<.001	1	2
SKIN	SLC25A15 →	+5.392	+4.824	.004	.004	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,590 associations by consensus.

SIGLEC12 by WAS expression — LARGE_INTESTINE

Explore this box plot interactively →