WARS2

Across TCGA patient cohorts, WARS2 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WARS2-associated genes across cancer lineages are FoxM1, JNK_pT183_Y185, and Chk2_pT68. Each is linked with WARS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both WARS2-to-partner and partner-to-WARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by WARS2-low versus WARS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WARS2→partner) and Y-score (partner→WARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.237	+1.906	.022	.016	3	3
COAD	JNK_pT183_Y185 →	-0.289	-3.000	.032	.035	3	3
UCEC	Chk2_pT68 →	-0.149	-2.449	.046	.019	3	3
UCEC	eEF2 →	+0.381	+2.321	.008	.033	3	2
UCEC	ERK2 →	+0.203	+3.169	.008	.018	3	2
UCEC	p70-S6K_pT389 →	-0.207	-2.690	.006	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

FoxM1 by WARS2 expression — UCEC

Explore this box plot interactively →