WARS2

Across TCGA cell cohorts, WARS2 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WARS2-associated genes across cancer lineages are ASPN, RASGEF1C, and KRTAP10-2. Each is linked with WARS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both WARS2-to-partner and partner-to-WARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASPN grouped by WARS2-low versus WARS2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WARS2→partner) and Y-score (partner→WARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ASPN →	+0.037	+3.426	.004	.007	3	1
LARGE_INTESTINE	RASGEF1C →	+0.240	+3.404	.002	.006	3	1
LARGE_INTESTINE	KRTAP10-2 →	+0.050	+2.994	<.001	.006	3	1
LARGE_INTESTINE	SPRR2F →	+0.434	+3.029	.003	.006	3	1
LARGE_INTESTINE	SH3GL2 →	+1.687	+3.252	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ASPN by WARS2 expression — LARGE_INTESTINE

Explore this box plot interactively →