WARS2-AS1

Across TCGA pan-cancer cohorts, WARS2-AS1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of WARS2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where WARS2-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types WARS2-AS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where WARS2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WARS2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.485	<.001	11	view →
THCA	Male	II,III,IV	−0.529	<.001	10	view →
LIHC	All	All	+0.392	<.001	8	view →
KICH	Female	All	−1.064	<.001	7	view →
STAD	All	II,III,IV	+0.547	<.001	6	view →
BRCA	Female	II,III,IV	−0.305	<.001	6	view →
BLCA	All	All	+0.473	.014	5	view →
COAD	Male	All	+0.358	.002	4	view →
CHOL	Female	All	+2.200	<.001	3	view →
PRAD	All	All	+0.564	<.001	2	view →
UCEC	All	All	−0.372	.012	2	view →
LUSC	Male	All	+0.305	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

WARS2-AS1–HNSC

Open the HNSC breakdown →