WARS1

Across TCGA pan-cancer cohorts, WARS1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of WARS1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where WARS1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types WARS1 is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

CCRCC, HNSC, and LSCC are the cancer types where WARS1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WARS1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	+0.440	<.001	10	view →
HNSC	Male	IV	+0.859	<.001	8	view →
LSCC	All	III,IV	−0.431	<.001	8	view →
COAD	Female	All	+0.397	<.001	7	view →
LUAD	All	II,III,IV	−0.338	<.001	6	view →
OV	All	All	+0.934	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

WARS1–CCRCC

Open the CCRCC breakdown →