WARS1

Across TCGA patient cohorts, WARS1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WARS1-associated genes across cancer lineages are PI3K-p85, Caspase-8, and Cyclin-B1. Each is linked with WARS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WARS1-to-partner and partner-to-WARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PI3K-p85 grouped by WARS1-low versus WARS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WARS1→partner) and Y-score (partner→WARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PI3K-p85 →	+0.166	+2.331	.048	.019	3	2
UCEC	Caspase-8 →	-0.253	-3.880	.012	<.001	3	2
UCEC	Cyclin-B1 →	+0.570	+1.906	.011	.016	3	2
SKCM	p38-MAPK_pT180_Y182 →	-0.419	-3.169	.027	.019	3	1
SKCM	4E-BP1_pT70 →	-0.274	-3.152	.005	.019	3	1
UCEC	EGFR →	-0.194	-2.973	.002	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

PI3K-p85 by WARS1 expression — UCEC

Explore this box plot interactively →