WARS1

Across TCGA cell cohorts, WARS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,991 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WARS1-associated GO terms across cancer lineages are Negative regulation of translation in response to endoplasmic reticulum stress, SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition, and Cotranslational protein targeting to membrane. Each is linked with WARS1 in more than 9 cancer types. Because this analysis shows association rather than direction, both WARS1-to-partner and partner-to-WARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of translation in response to endoplasmic reticulum stress grouped by WARS1-low versus WARS1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WARS1→partner) and Y-score (partner→WARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of translation in response to endoplasmic reticulum stress →	+0.184	+1.423	<.001	<.001	3	9
LARGE_INTESTINE	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition →	+0.116	+1.105	<.001	<.001	3	9
OESOPHAGUS	Cotranslational protein targeting to membrane →	+0.134	+1.520	.001	.001	2	10
BLOOD_Leukemia	Response to acid chemical →	+0.058	+1.383	<.001	<.001	3	9
OVARY	Formate metabolic process →	+0.108	+0.961	.005	.006	3	9
LARGE_INTESTINE	Formate biosynthetic process →	+0.092	+0.853	.004	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,991 associations by consensus.

Negative regulation of translation in response to endoplasmic reticulum stress by WARS1 expression — BONE

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