WARS1

Across TCGA cell cohorts, WARS1 mutation is significantly associated with the mutation status of many other genes, with 3,825 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WARS1-associated genes across cancer lineages are ADAMTS7, CLIP2, and NEBL. Each is linked with WARS1 in more than 3 cancer types. Because this analysis shows association rather than direction, both WARS1-to-partner and partner-to-WARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAMTS7 grouped by WARS1-low versus WARS1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WARS1→partner) and Y-score (partner→WARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ADAMTS7 →	+3.357	+4.285	.005	.005	1	4
BLOOD_Leukemia	CLIP2 →	+4.000	+5.050	.008	.008	1	3
BLOOD_Leukemia	NEBL →	+4.321	+5.285	.005	.005	1	3
LUNG_NSCLC_LUAD	TPCN2 →	+4.187	+5.000	.008	.008	1	3
LARGE_INTESTINE	ZNF839 →	+2.248	+2.445	.003	.003	1	3
LUNG_NSCLC_LUAD	PRICKLE1 →	+4.187	+5.000	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,825 associations by consensus.

ADAMTS7 by WARS1 expression — STOMACH

Explore this box plot interactively →