VWC2L

Across TCGA patient cohorts, VWC2L mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VWC2L-associated genes across cancer lineages are eIF4E, p21, and TFRC. Each is linked with VWC2L in more than 1 cancer types. Because this analysis shows association rather than direction, both VWC2L-to-partner and partner-to-VWC2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by VWC2L-low versus VWC2L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWC2L→partner) and Y-score (partner→VWC2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.166	+3.013	.040	.018	3	2
UCEC	p21 →	+0.219	+3.700	.003	.001	3	2
UCEC	TFRC →	+0.660	+2.584	.001	.001	3	2
UCEC	4E-BP1 →	+0.344	+2.584	<.001	.001	3	2
UCEC	C-Raf →	+0.242	+3.459	<.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.359	-3.906	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

eIF4E by VWC2L expression — UCEC

Explore this box plot interactively →