Across TCGA patient cohorts, VWC2 mutation is significantly associated with the RNA expression of many other genes, with 1,777 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VWC2-associated genes across cancer lineages are DAPK3, PIDD1, and SPATA20. Each is linked with VWC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both VWC2-to-partner and partner-to-VWC2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWC2→partner) and Y-score (partner→VWC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DAPK3 →	+0.519	+3.330	.001	.005	3	2
UCEC	PIDD1 →	+0.641	+2.354	<.001	.003	3	2
UCEC	SPATA20 →	+0.594	+3.608	.001	.001	3	2
UCEC	PLEKHH3 →	+0.720	+3.010	<.001	<.001	3	2
SKCM	RNU6-1150P →	+0.279	+3.699	<.001	.003	3	2
LUAD	RPSAP64 →	+0.373	+3.415	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,777 associations by consensus.

Exploration

VWC2 survival (RNA) · tumor vs normal (RNA) · all VWC2 data types