Across TCGA patient cohorts, VWC2 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VWC2-associated genes across cancer lineages are eIF4E, ATM, and EGFR_pY1068. Each is linked with VWC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both VWC2-to-partner and partner-to-VWC2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWC2→partner) and Y-score (partner→VWC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.198	+3.013	.026	.018	3	2
UCEC	ATM →	-0.615	-3.156	.001	.018	3	2
UCEC	EGFR_pY1068 →	-0.271	-2.906	.011	.001	3	1
UCEC	ERK2 →	+0.258	+3.321	.001	.009	3	1
UCEC	FOXO3a_pS318_S321 →	-0.110	-2.575	.038	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.143	-2.584	.045	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

VWC2 survival (RNA) · tumor vs normal (RNA) · all VWC2 data types