Across TCGA cell cohorts, VWC2 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible VWC2-associated genes across cancer lineages are PIK3CG, MNDA, and HOATZ. Each is linked with VWC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both VWC2-to-partner and partner-to-VWC2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWC2→partner) and Y-score (partner→VWC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PIK3CG →	+0.134	+3.370	.008	.008	3	1
LUNG_NSCLC_LUAD	MNDA →	+0.064	+3.466	.003	.009	3	1
LUNG_NSCLC_LUAD	HOATZ →	+0.545	+3.614	.005	.006	3	1
LUNG_NSCLC_LUAD	LILRA5 →	+0.021	+3.189	<.001	.007	3	1
LUNG_NSCLC_LUAD	POM121L12 →	+0.012	+3.944	<.001	.006	3	1
SKIN	CYLC1 →	+0.009	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

VWC2 survival (RNA) · tumor vs normal (RNA) · all VWC2 data types