Across TCGA pan-cancer cohorts, VWA8P1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of VWA8P1’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where VWA8P1 RNA is repressed in tumor relative to normal tissue. In most cancer types VWA8P1 is over-expressed in tumor, although a few such as KIRC and ESCA show the opposite, repressed pattern.
KIRC and ESCA are the cancer types where VWA8P1 tumor–normal differential expression is most reproducible.