VWA5B2

Across TCGA patient cohorts, VWA5B2 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VWA5B2-associated genes across cancer lineages are ASNS, GAPDH, and eEF2. Each is linked with VWA5B2 in more than 2 cancer types. Because this analysis shows association rather than direction, both VWA5B2-to-partner and partner-to-VWA5B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by VWA5B2-low versus VWA5B2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWA5B2→partner) and Y-score (partner→VWA5B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.621	+3.169	<.001	.018	3	3
COAD	GAPDH →	+0.527	+2.182	.016	.033	3	2
UCEC	eEF2 →	+0.337	+1.652	.004	.006	3	2
UCEC	NF2 →	+0.248	+1.584	<.001	.032	3	2
UCEC	p21 →	+0.145	+1.598	.021	.040	3	2
UCEC	TFRC →	+0.601	+2.807	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

ASNS by VWA5B2 expression — COAD

Explore this box plot interactively →