VWA5B2

Across TCGA cell cohorts, VWA5B2 mutation is significantly associated with the drug of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VWA5B2-associated genes across cancer lineages are Nutlin-3a (-), Pevonedistat, and OSI-027. Each is linked with VWA5B2 in more than 1 cancer types. Because this analysis shows association rather than direction, both VWA5B2-to-partner and partner-to-VWA5B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nutlin-3a (-) grouped by VWA5B2-low versus VWA5B2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWA5B2→partner) and Y-score (partner→VWA5B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Nutlin-3a (-) →	+0.878	+2.646	.015	.047	3	1
LARGE_INTESTINE	Pevonedistat →	+0.728	+2.649	.034	.046	3	1
LARGE_INTESTINE	OSI-027 →	+0.516	+2.769	.017	.040	3	1
LARGE_INTESTINE	720427 →	+0.330	+2.649	.011	.046	3	1
LARGE_INTESTINE	BX-912 →	+0.637	+2.652	.028	.045	3	1
LARGE_INTESTINE	Alectinib →	+0.483	+2.786	.004	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Nutlin-3a (-) by VWA5B2 expression — LARGE_INTESTINE

Explore this box plot interactively →