VWA5A

Across TCGA pan-cancer cohorts, VWA5A mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of VWA5A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where VWA5A mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types VWA5A is over-expressed in tumor, although a few such as COAD and CCRCC show the opposite, repressed pattern.

COAD, CCRCC, and HNSC are the cancer types where VWA5A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VWA5A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−0.840	<.001	12	view →
CCRCC	All	IV	−0.412	<.001	12	view →
HNSC	Male	III,IV	−0.638	<.001	11	view →
LSCC	Female	II,III,IV	−0.900	<.001	9	view →
LUAD	Male	All	−0.259	<.001	4	view →
OV	All	All	−0.308	.030	2	view →
PDAC	All	All	+0.176	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

VWA5A–COAD

Open the COAD breakdown →