VWA2

Across TCGA pan-cancer cohorts, VWA2 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated VWA2 data layer compared with 25 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher VWA2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated VWA2 expression acts as an unfavorable survival marker, although some lineages such as MESO and SKCM show a favorable association.

HNSC, BLCA, and READ are the cancer types where VWA2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.122	0.696	<.001	45	view →
BLCA	OS	Median	IV	0.130	0.599	.002	12	view →
READ	DFS	Median	All	0.182	0.798	.010	9	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
ESCA	OS	Median	II,III,IV	0.216	0.702	.014	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
MESO	DFS	Median	All	1.000	0.179	.041	3	view →
SKCM	DFS	Median	All	0.242	0.214	.021	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

VWA2–HNSC (DFS)

Open the HNSC breakdown →