VWA2

Across TCGA pan-cancer cohorts, VWA2 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated VWA2 data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher VWA2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated VWA2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC and PDAC are the cancer types where VWA2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.887	0.615	.007	20	view →
PDAC	DFS	Median	III,IV	0.928	0.287	<.001	9	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

VWA2–CCRCC (DFS)

Open the CCRCC breakdown →