VWA2

Across TCGA patient cohorts, VWA2 protein abundance is significantly associated with the RNA expression of many other genes, with 7,050 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible VWA2-associated genes across cancer lineages are SPATA7, CENPA, and SGO1. Each is linked with VWA2 in more than 4 cancer types. Because this analysis shows association rather than direction, both VWA2-to-partner and partner-to-VWA2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VWA2 versus SPATA7 in BRCA, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWA2→partner) and Y-score (partner→VWA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SPATA7 →	+0.415	+0.601	.001	<.001	3	5
UCEC	CENPA →	-0.826	-0.722	.001	.003	3	4
UCEC	SGO1 →	-0.842	-0.766	<.001	<.001	3	4
OV	CEP55 →	-1.648	-1.059	<.001	.001	3	4
BRCA	SLC44A3 →	+0.728	+0.643	<.001	.002	3	4
BRCA	SERP2 →	+0.939	+0.627	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,050 associations by consensus.

VWA2 vs SPATA7 — BRCA

Explore this scatter interactively →