VWA2

Across TCGA patient cohorts, VWA2 mutation is significantly associated with the RNA expression of many other genes, with 3,165 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VWA2-associated genes across cancer lineages are HMG20B, ARMC7, and CIRBP-AS1. Each is linked with VWA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both VWA2-to-partner and partner-to-VWA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMG20B grouped by VWA2-low versus VWA2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWA2→partner) and Y-score (partner→VWA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HMG20B →	+0.405	+2.597	.005	.005	3	3
UCEC	ARMC7 →	+0.475	+2.823	.002	.001	3	3
UCEC	CIRBP-AS1 →	+0.691	+2.978	<.001	<.001	3	3
UCEC	ATP2A1 →	+0.387	+3.609	.002	.001	3	3
READ	MIR5089 →	+0.837	+5.653	<.001	.003	3	2
SKCM	DVL1 →	+0.345	+1.518	.007	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,165 associations by consensus.

HMG20B by VWA2 expression — SKCM

Explore this box plot interactively →