VWA2

Across TCGA cell cohorts, VWA2 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible VWA2-associated genes across cancer lineages are CLDN34, SLC32A1, and LGI1. Each is linked with VWA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both VWA2-to-partner and partner-to-VWA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLDN34 grouped by VWA2-low versus VWA2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWA2→partner) and Y-score (partner→VWA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CLDN34 →	+0.054	+4.984	<.001	.002	3	2
BLOOD_Leukemia	SLC32A1 →	+0.619	+3.901	<.001	.006	3	1
BLOOD_Leukemia	LGI1 →	+0.079	+5.124	<.001	<.001	3	1
BLOOD_Leukemia	RPE65 →	+0.054	+4.060	<.001	.003	3	1
BLOOD_Leukemia	MMP27 →	+0.015	+4.384	<.001	.006	3	1
BLOOD_Leukemia	METTL21C →	+0.033	+4.133	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

CLDN34 by VWA2 expression — BLOOD_Leukemia

Explore this box plot interactively →