VWA1

Across TCGA patient cohorts, VWA1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VWA1-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and ERK2. Each is linked with VWA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VWA1-to-partner and partner-to-VWA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by VWA1-low versus VWA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWA1→partner) and Y-score (partner→VWA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.277	-2.459	.022	.020	3	1
UCEC	A-Raf_pS299 →	-0.155	-3.000	.007	.036	3	1
UCEC	ERK2 →	+0.220	+2.459	.018	.020	3	1
UCEC	Rab25 →	-0.369	-3.000	.021	.036	3	1
UCEC	STAT3_pY705 →	-0.355	-2.999	.005	.035	3	1
UCEC	VHL →	-1.239	-3.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by VWA1 expression — UCEC

Explore this box plot interactively →