VWA1

Across TCGA cell cohorts, VWA1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible VWA1-associated genes across cancer lineages are CRYAA, OR1N1, and PRND. Each is linked with VWA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VWA1-to-partner and partner-to-VWA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRYAA grouped by VWA1-low versus VWA1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWA1→partner) and Y-score (partner→VWA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CRYAA →	+0.090	+3.705	<.001	.007	3	1
BLOOD_Leukemia	OR1N1 →	+0.073	+4.234	<.001	.003	3	1
BLOOD_Leukemia	PRND →	+0.009	+3.874	<.001	.005	3	1
BLOOD_Leukemia	CCT8L2 →	+0.011	+3.874	<.001	.005	3	1
LARGE_INTESTINE	NAA11 →	+0.315	+3.472	.004	.005	3	1
LARGE_INTESTINE	CX3CR1 →	+0.166	+3.252	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

CRYAA by VWA1 expression — BLOOD_Leukemia

Explore this box plot interactively →