VTN

Across TCGA pan-cancer cohorts, VTN mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated VTN data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher VTN mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated VTN expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

COAD, LUAD, and PDAC are the cancer types where VTN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.879	1.000	.019	78	view →
LUAD	OS	Median	III,IV	0.213	0.677	.003	29	view →
PDAC	OS	Median	II,III,IV	0.681	0.945	.001	24	view →
CCRCC	OS	Median	IV	0.785	0.123	.009	13	view →
UCEC	OS	Tertile	All	0.896	1.000	.026	12	view →
GBM	DFS	Quartile	All	0.255	0.522	.015	4	view →
LSCC	DFS	Quartile	II,III,IV	0.838	1.000	.032	1	view →
HNSC	DFS	Median	II,III,IV	0.567	0.720	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

VTN–COAD (DFS)

Open the COAD breakdown →