VTN

Across TCGA patient cohorts, VTN mutation is significantly associated with the RNA expression of many other genes, with 472 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VTN-associated genes across cancer lineages are OR7E8P, LINC00692, and PHF5A. Each is linked with VTN in more than 1 cancer types. Because this analysis shows association rather than direction, both VTN-to-partner and partner-to-VTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR7E8P grouped by VTN-low versus VTN-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VTN→partner) and Y-score (partner→VTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	OR7E8P →	+0.045	+5.201	<.001	.007	3	2
CESC	LINC00692 →	+0.041	+6.837	<.001	<.001	3	2
COAD	PHF5A →	+0.459	+3.210	.005	.009	3	2
COAD	PDHX →	+0.400	+3.389	.006	.004	3	2
UCEC	COPS3 →	+0.569	+3.212	.003	.009	3	2
COAD	GFI1 →	+0.875	+3.348	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 472 associations by consensus.

OR7E8P by VTN expression — CESC

Explore this box plot interactively →