VTN

Across TCGA patient cohorts, VTN mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VTN-associated genes across cancer lineages are 4E-BP1, eIF4E, and eIF4G. Each is linked with VTN in more than 2 cancer types. Because this analysis shows association rather than direction, both VTN-to-partner and partner-to-VTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by VTN-low versus VTN-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VTN→partner) and Y-score (partner→VTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	4E-BP1 →	+0.309	+3.008	.006	.019	3	3
UCEC	eIF4E →	+0.248	+3.169	.032	.020	3	1
UCEC	eIF4G →	+0.483	+3.169	.004	.020	3	1
UCEC	JNK_pT183_Y185 →	-0.225	-3.156	.015	.020	3	1
UCEC	STAT3_pY705 →	-0.569	-3.169	<.001	.020	3	1
UCEC	Cyclin-B1 →	+0.927	+3.000	.002	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

4E-BP1 by VTN expression — COAD

Explore this box plot interactively →