VTI1B

Across TCGA pan-cancer cohorts, VTI1B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated VTI1B data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher VTI1B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated VTI1B expression acts as an unfavorable survival marker, although some lineages such as HNSC and OV show a favorable association.

HNSC, LUAD, and COAD are the cancer types where VTI1B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.766	0.492	.006	22	view →
LUAD	OS	Median	III,IV	0.611	0.995	.022	15	view →
COAD	DFS	Tertile	All	0.859	1.000	.033	12	view →
OV	DFS	Median	All	1.000	0.878	.048	4	view →
LSCC	DFS	Median	III,IV	1.000	0.867	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

VTI1B–HNSC (DFS)

Open the HNSC breakdown →