VTI1A

Across TCGA patient cohorts, VTI1A mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VTI1A-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and A-Raf_pS299. Each is linked with VTI1A in more than 1 cancer types. Because this analysis shows association rather than direction, both VTI1A-to-partner and partner-to-VTI1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by VTI1A-low versus VTI1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VTI1A→partner) and Y-score (partner→VTI1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.149	-3.571	.002	.002	3	1
UCEC	EGFR_pY1068 →	-0.367	-2.459	.002	.020	3	1
UCEC	A-Raf_pS299 →	-0.160	-2.459	.005	.020	3	1
UCEC	JNK_pT183_Y185 →	-0.174	-2.446	.032	.020	3	1
UCEC	MYH11 →	+1.176	+2.459	.034	.020	3	1
UCEC	PDK1_pS241 →	+0.197	+3.000	.017	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

14-3-3_beta by VTI1A expression — UCEC

Explore this box plot interactively →