VSTM2A

Across TCGA pan-cancer cohorts, VSTM2A Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated VSTM2A data layer compared with 21 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher VSTM2A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated VSTM2A expression acts as an unfavorable survival marker.

HNSC, GBM, and READ are the cancer types where VSTM2A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.156	0.751	<.001	48	view →
GBM	DFS	Median	All	0.043	0.257	<.001	12	view →
READ	OS	Median	III,IV	0.287	0.748	.001	12	view →
LUAD	OS	Median	III,IV	0.223	0.677	.006	12	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	OS	Median	IV	0.415	0.861	.014	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

VSTM2A–HNSC (OS)

Open the HNSC breakdown →