VSTM2A

Across TCGA patient cohorts, VSTM2A mutation is significantly associated with the RNA expression of many other genes, with 3,983 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VSTM2A-associated genes across cancer lineages are THOC5, CDC20, and HMGB3. Each is linked with VSTM2A in more than 3 cancer types. Because this analysis shows association rather than direction, both VSTM2A-to-partner and partner-to-VSTM2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, THOC5 grouped by VSTM2A-low versus VSTM2A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VSTM2A→partner) and Y-score (partner→VSTM2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	THOC5 →	+0.484	+2.449	.001	<.001	3	4
SKCM	CDC20 →	+0.616	+2.434	.003	.001	3	4
SKCM	HMGB3 →	+0.557	+2.398	.004	<.001	3	4
UCEC	MAP6D1 →	+0.473	+2.807	.004	.003	3	4
UCEC	RNU6-218P →	+0.400	+1.667	.001	.005	3	4
UCEC	CHEK1 →	+0.857	+4.021	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,983 associations by consensus.

THOC5 by VSTM2A expression — SKCM

Explore this box plot interactively →