VSTM2A

Across TCGA cell cohorts, VSTM2A mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible VSTM2A-associated genes across cancer lineages are ASPN, OTP, and PROP1. Each is linked with VSTM2A in more than 1 cancer types. Because this analysis shows association rather than direction, both VSTM2A-to-partner and partner-to-VSTM2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASPN grouped by VSTM2A-low versus VSTM2A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VSTM2A→partner) and Y-score (partner→VSTM2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ASPN →	+0.045	+3.648	<.001	.002	3	1
LARGE_INTESTINE	OTP →	+0.068	+3.339	<.001	.007	3	1
LARGE_INTESTINE	PROP1 →	+0.027	+2.791	<.001	.005	3	1
LUNG_NSCLC_LUAD	TBATA →	+0.189	+3.544	<.001	.009	3	1
BLOOD_Leukemia	PHOX2B →	+0.018	+4.365	<.001	.002	3	1
BLOOD_Leukemia	LCE2A →	+0.042	+4.384	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

ASPN by VSTM2A expression — LARGE_INTESTINE

Explore this box plot interactively →