VSNL1

Across TCGA pan-cancer cohorts, VSNL1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of VSNL1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where VSNL1 RNA is repressed in tumor relative to normal tissue. In most cancer types VSNL1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, COAD, and KICH are the cancer types where VSNL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VSNL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−1.176	<.001	12	view →
COAD	Female	II,III,IV	+2.747	<.001	11	view →
KICH	Female	All	−1.452	<.001	10	view →
LUSC	Female	II,III,IV	+3.522	<.001	7	view →
HNSC	All	All	+0.939	<.001	7	view →
BRCA	Female	All	−0.870	<.001	6	view →
LUAD	All	All	−0.397	.009	4	view →
CHOL	Female	All	−3.376	<.001	3	view →
READ	All	All	+2.955	<.001	3	view →
PRAD	All	All	−1.350	<.001	2	view →
LIHC	Female	All	−0.944	.023	1	view →
LIHC	Male	All	+0.559	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

VSNL1–KIRC

Open the KIRC breakdown →