VSIR

RNA expression — cross-omics
Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, VSIR RNA expression is significantly associated with the protein abundance of many other proteins, with 19,569 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible VSIR-associated proteins across cancer lineages are RCSD1, HCLS1, and RASAL3. Each is linked with VSIR in more than 9 cancer types. Because this analysis shows association rather than direction, both VSIR-to-partner and partner-to-VSIR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VSIR versus RCSD1 in LSCC, with a Pearson correlation of 0.69.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (VSIR→partner) and Y-score (partner→VSIR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCRCSD1 →+0.631+0.787<.001<.001310
GBMHCLS1 →+0.750+1.021<.001<.001310
OVRASAL3 →+0.535+0.935<.001<.00139
OVCORO1A →+0.845+1.140<.001<.00139
OVDOCK8 →+0.553+0.891<.001<.00139
LSCCFNBP1 →+0.428+0.695<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 19,569 associations by consensus.

VSIR vs RCSD1 — LSCC

Per-sample scatter of VSIR vs RCSD1 in LSCC (Pearson r = 0.69).

Explore this scatter interactively →

Exploration