VSIR

Across TCGA patient cohorts, VSIR protein abundance is significantly associated with the RNA expression of many other genes, with 20,148 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible VSIR-associated genes across cancer lineages are SAMSN1, CLEC4E, and SELL. Each is linked with VSIR in more than 8 cancer types. Because this analysis shows association rather than direction, both VSIR-to-partner and partner-to-VSIR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VSIR versus SAMSN1 in GBM, with a Pearson correlation of 0.77.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VSIR→partner) and Y-score (partner→VSIR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SAMSN1 →	+1.137	+0.731	<.001	<.001	3	9
OV	CLEC4E →	+1.058	+0.478	.003	<.001	3	9
GBM	SELL →	+1.598	+0.746	<.001	<.001	3	9
GBM	EBI3 →	+1.088	+0.685	<.001	<.001	3	8
HNSC	KYNU →	+1.062	+0.367	<.001	<.001	3	8
HNSC	LILRA5 →	+0.921	+0.339	.003	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,148 associations by consensus.

VSIR vs SAMSN1 — GBM

Explore this scatter interactively →