VSIR

Across TCGA patient cohorts, VSIR mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VSIR-associated genes across cancer lineages are MEK1, Myosin-IIa_pS1943, and VHL. Each is linked with VSIR in more than 1 cancer types. Because this analysis shows association rather than direction, both VSIR-to-partner and partner-to-VSIR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by VSIR-low versus VSIR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VSIR→partner) and Y-score (partner→VSIR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.447	+3.000	.034	.036	3	1
UCEC	Myosin-IIa_pS1943 →	+0.262	+3.013	.028	.019	3	1
UCEC	VHL →	-0.969	-3.000	.013	.037	3	1
UCEC	4E-BP1_pT37_T46 →	-0.633	-3.000	.003	.037	3	1
UCEC	Ku80 →	+0.290	+3.013	.033	.019	1	1
UCEC	MAPK_pT202_Y204 →	-0.566	-3.000	.037	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MEK1 by VSIR expression — UCEC

Explore this box plot interactively →