VSIR

Across TCGA cell cohorts, VSIR RNA expression is significantly associated with the go_rna of many other GO terms, with 5,871 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible VSIR-associated GO terms across cancer lineages are Membrane protein proteolysis, Regulation of protein localization to plasma membrane, and Cell-substrate adhesion. Each is linked with VSIR in more than 14 cancer types. Because this analysis shows association rather than direction, both VSIR-to-partner and partner-to-VSIR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Membrane protein proteolysis grouped by VSIR-low versus VSIR-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VSIR→partner) and Y-score (partner→VSIR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Membrane protein proteolysis →	+0.092	+1.674	<.001	<.001	3	15
BONE	Regulation of protein localization to plasma membrane →	+0.129	+2.901	<.001	<.001	3	14
BONE	Cell-substrate adhesion →	+0.149	+2.874	.001	<.001	3	14
BONE	Positive regulation of canonical NF-kappaB signal transduction →	+0.049	+1.983	.006	.003	3	14
OVARY	Positive regulation of cytokine-mediated signaling pathway →	+0.116	+2.376	<.001	<.001	3	14
BONE	Regulation of cell-substrate adhesion →	+0.127	+2.837	.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,871 associations by consensus.

Membrane protein proteolysis by VSIR expression — LARGE_INTESTINE

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