VSIG8

Across TCGA patient cohorts, VSIG8 mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VSIG8-associated genes across cancer lineages are Astrocytes, Erythrocytes, and Fibroblasts. Each is linked with VSIG8 in more than 1 cancer types. Because this analysis shows association rather than direction, both VSIG8-to-partner and partner-to-VSIG8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Astrocytes grouped by VSIG8-low versus VSIG8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VSIG8→partner) and Y-score (partner→VSIG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Astrocytes →	+0.071	+2.410	<.001	.043	3	2
UCEC	Erythrocytes →	+0.042	+3.010	<.001	.019	3	2
SKCM	Fibroblasts →	+0.013	+4.475	<.001	.005	3	1
UCEC	lymphatic Endothelial cells →	-0.023	-3.138	.035	.019	3	1
UCEC	mv Endothelial cells →	-0.029	-3.169	.008	.019	3	1
UCEC	Endothelial cells →	-0.044	-2.542	.012	.011	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Astrocytes by VSIG8 expression — SKCM

Explore this box plot interactively →