VSIG8

Across TCGA cell cohorts, VSIG8 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,717 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible VSIG8-associated GO terms across cancer lineages are Positive regulation of cytokine-mediated signaling pathway, Cerebral cortex radially oriented cell migration, and Intracellular potassium ion homeostasis. Each is linked with VSIG8 in more than 5 cancer types. Because this analysis shows association rather than direction, both VSIG8-to-partner and partner-to-VSIG8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cytokine-mediated signaling pathway grouped by VSIG8-low versus VSIG8-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VSIG8→partner) and Y-score (partner→VSIG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Positive regulation of cytokine-mediated signaling pathway →	+0.094	+0.045	<.001	.003	3	6
LIVER	Cerebral cortex radially oriented cell migration →	+0.153	+0.048	.002	.001	3	5
SOFT_TISSUE	Intracellular potassium ion homeostasis →	+0.179	+0.027	<.001	.005	3	5
SOFT_TISSUE	Substrate adhesion-dependent cell spreading →	+0.157	+0.027	<.001	<.001	3	5
BLOOD_Myeloma	Response to tumor necrosis factor →	+0.048	+0.020	.006	.008	3	5
SOFT_TISSUE	Pyroptotic inflammatory response →	+0.108	+0.032	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,717 associations by consensus.

Positive regulation of cytokine-mediated signaling pathway by VSIG8 expression — LIVER

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