VSIG8

Across TCGA cell cohorts, VSIG8 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VSIG8-associated genes across cancer lineages are TBC1D21, OR52H1, and PSMB11. Each is linked with VSIG8 in more than 1 cancer types. Because this analysis shows association rather than direction, both VSIG8-to-partner and partner-to-VSIG8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D21 grouped by VSIG8-low versus VSIG8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VSIG8→partner) and Y-score (partner→VSIG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR52H1 →	+0.031	+4.669	<.001	<.001	3	1
LARGE_INTESTINE	PSMB11 →	+0.025	+3.878	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

TBC1D21 by VSIG8 expression — LARGE_INTESTINE

Explore this box plot interactively →