VSIG4

Across TCGA pan-cancer cohorts, VSIG4 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated VSIG4 data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher VSIG4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated VSIG4 expression acts as an unfavorable survival marker, although some lineages such as LIHC and BLCA show a favorable association.

KIRC, HNSC, and COAD are the cancer types where VSIG4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.133	0.805	<.001	42	view →
HNSC	DFS	Median	II,III,IV	0.122	0.685	.001	33	view →
COAD	OS	Median	III,IV	0.105	0.800	<.001	22	view →
STAD	DFS	Median	All	0.089	0.630	<.001	18	view →
SKCM	DFS	Median	II,III,IV	0.087	0.708	<.001	6	view →
PCPG	DFS	Median	All	0.167	0.819	.010	3	view →
LIHC	DFS	Median	All	1.000	0.284	.036	3	view →
BLCA	DFS	Median	II,III,IV	1.000	0.608	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

VSIG4–KIRC (OS)

Open the KIRC breakdown →