VSIG4

Across TCGA pan-cancer cohorts, VSIG4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated VSIG4 data layer compared with 23 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher VSIG4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated VSIG4 expression acts as an unfavorable survival marker.

COAD, CCRCC, and GBM are the cancer types where VSIG4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.911	1.000	.012	90	view →
CCRCC	OS	Quartile	All	0.417	0.918	.013	43	view →
GBM	DFS	Quartile	All	0.590	0.818	.004	22	view →
UCEC	DFS	Tertile	All	0.827	0.954	.038	6	view →
PDAC	OS	Median	II,III,IV	0.769	0.909	.019	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

VSIG4–COAD (DFS)

Open the COAD breakdown →